As I usually jump between 1 monitor setups and 2 monitor setups. This always happens. The dang Vray frame buffer goes missing. This seems to solve it, but I have only tested it once today.
1) Open the scene;
2) Before any rendering is done (this is important!) open the script editor and type this MEL command:
setAttr "vraySettings.vfbSettingsArr" -type Int32Array 0;
I do love simple solutions that work. Please make this work...always.